Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.40 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714085 | 0.89 | PIK3CA (0.41) | AKT1PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1579169 | 0.80 | PIK3CA (0.58) | AKT1PIK3CAPIK3CBPIK3CGRAF1 | |
| SCHEMBL31330604 | 0.80 | PIK3CA (0.38) | PIK3CAPIK3CBPIK3CDEIF2AK4PDE10A | |
| SCHEMBL34470523 | 0.80 | PIK3CA (0.38) | PIK3CAPIK3CBPIK3CDEIF2AK4PDE10A | |
| SCHEMBL3709425 | 0.77 | LMNA (0.46) | PIK3CAPIK3CB | |
| SCHEMBL3711296 | 0.76 | LMNA (0.41) | PIK3CAPIK3CBPDE10A | |
| SCHEMBL21796865 | 0.76 | PIK3CD (0.44) | AKT1PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL13188830 | 0.76 | LMNA (0.48) | PIK3CAPIK3CB | |
| SCHEMBL18399228 | 0.76 | PIK3CD (0.44) | AKT1PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL3710227 | 0.76 | LMNA (0.48) | PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |