Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | VHL | P40337 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3133083 | 1.00 | MAPK1 (0.39) | MAPK1RXFP1PTGER1ROCK2POLB | |
| SCHEMBL3121405 | 0.91 | BCHE (0.39) | MAPK1PTGER1ULK1CCNE1CDK2 | |
| SCHEMBL3121408 | 0.91 | BCHE (0.39) | MAPK1PTGER1ULK1CCNE1CDK2 | |
| SCHEMBL3124781 | 0.87 | NPC1 (0.48) | MAPK1PTGER1POLB | |
| SCHEMBL3124806 | 0.87 | NPC1 (0.48) | MAPK1PTGER1POLB | |
| SCHEMBL3124791 | 0.87 | NPC1 (0.48) | MAPK1PTGER1POLB | |
| SCHEMBL3127315 | 0.86 | PKM (0.40) | MAPK1KMT2AP2RX7CCNE1CDK2 | |
| SCHEMBL3127326 | 0.86 | PKM (0.40) | MAPK1KMT2AP2RX7CCNE1CDK2 | |
| SCHEMBL3557894 | 0.83 | ALDH1A1 (0.44) | CDK2 | |
| SCHEMBL3557896 | 0.83 | ALDH1A1 (0.44) | CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689721-B1 | AMINOPYRAZOLE DERIVATIVES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2010-07-14 | — | — | EP | claimed |
| US-7671072-B2 | Aminopyrazole derivatives as GSK-3 inhibitors | PFIZER INC. (US) | 2010-03-02 | — | — | US | claimed |
| EP-1689721-B1 | AMINOPYRAZOLE DERIVATIVES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2010-07-14 | — | — | EP | disclosed |