SCHEMBL31332483

SCHEMBL31332483

O=C(O)c1[nH]c2ccc(F)c(Cl)c2c1F

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAP2 P11137 2/20 0.43
GPR17 Q13304 3/20 0.42
EIF4A3 P38919 1/20 0.40
DAO P14920 1/20 0.40
AR P10275 1/20 0.37
JAK2 O60674 1/20 0.37
THRB P10828 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31332568 0.88 MAP2 (0.41) MAP2GPR17DAOAR
SCHEMBL31416433 0.87 MAP2 (0.49) MAP2GPR17EIF4A3AR
SCHEMBL27397857 0.85 DAO (0.42) MAP2GPR17DAOAR
SCHEMBL31171910 0.84 EIF4A3 (0.43) MAP2GPR17EIF4A3DAOJAK2
SCHEMBL19331084 0.84 MEN1 (0.41) MAP2GPR17DAOAR
SCHEMBL8959566 0.80 PRNP (0.48) GPR17
SCHEMBL27805830 0.77 GPR17 (0.58) MAP2GPR17EIF4A3
SCHEMBL31332498 0.76 PTGS2 (0.50)
SCHEMBL22760181 0.75 MAP2 (0.42) MAP2
SCHEMBL31416150 0.75 HRH4 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747234-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS Muna Therapeutics ApS (DK) 2026-05-27 EP disclosed
EP-4747235-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS Muna Therapeutics ApS (DK) 2026-05-27 EP disclosed
WO-2025017105-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS MUNA THERAPEUTICS APS (DK) 2025-01-23 WO disclosed
WO-2025017103-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS MUNA THERAPEUTICS APS (DK) 2025-01-23 WO disclosed