Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | GPR17 | Q13304 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31332568 | 0.82 | MAP2 (0.41) | GPR17 | |
| SCHEMBL19331084 | 0.81 | MEN1 (0.41) | GPR17 | |
| SCHEMBL6594503 | 0.81 | MAPT (0.47) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL31332483 | 0.80 | MAP2 (0.43) | GPR17 | |
| SCHEMBL9228790 | 0.80 | SIRT1 (0.35) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL27397857 | 0.79 | DAO (0.42) | GPR17 | |
| SCHEMBL23000272 | 0.77 | PRNP (0.55) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL4916175 | 0.74 | KDM4E (0.50) | CYP1A2CYP2C19MAPT | |
| SCHEMBL266498 | 0.74 | GPR17 (0.70) | CYP1A2CYP2C9CYP2C19GPR17 | |
| SCHEMBL2538695 | 0.74 | PRNP (0.69) | PRNPCYP1A2CYP2C9CYP2C19PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |