SCHEMBL31333583

SCHEMBL31333583

O=C(O)CN1CCC(CN2CCN(c3ccc(NC4CCC(=O)NC4=O)cc3F)CC2)CC1

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 18/20 0.46
DDB1 Q16531 17/20 0.46
MAPT P10636 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30120164 0.94 CRBN (0.52) CRBNDDB1MAPTL3MBTL1
SCHEMBL23799117 0.94 CRBN (0.52) CRBNDDB1MAPTL3MBTL1
SCHEMBL31333201 0.90 CRBN (0.44) CRBNDDB1LMNA
SCHEMBL31334602 0.90 CRBN (0.47) CRBNDDB1
SCHEMBL31334758 0.89 CRBN (0.44) CRBNDDB1LMNA
SCHEMBL31333759 0.89 CRBN (0.47) CRBNDDB1MAPT
SCHEMBL31334549 0.89 CRBN (0.48) CRBNDDB1LMNA
SCHEMBL31639567 0.89 CRBN (0.43) CRBNDDB1LMNA
SCHEMBL29179902 0.88 DDB1 (0.49) CRBNDDB1
SCHEMBL31639501 0.88 CRBN (0.49) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed