SCHEMBL31334019

SCHEMBL31334019

COC(=O)[C@H]1CC[C@H](Nc2ncc(F)c(-c3ccnc(C4(O)CCC4)c3)n2)CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 5/20 0.38
PDGFRB P09619 1/20 0.38
PDGFRA P16234 1/20 0.38
DYRK2 Q92630 7/20 0.37
CDK2 P24941 2/20 0.37
CCNB2 O95067 1/20 0.37
CCNE2 O96020 1/20 0.37
CDK1 P06493 1/20 0.37
CCNB1 P14635 1/20 0.37
CCNE1 P24864 1/20 0.37
CDK5 Q00535 1/20 0.37
CDK5R1 Q15078 1/20 0.37
CCNB3 Q8WWL7 1/20 0.37
CCNA2 P20248 1/20 0.36
MAPK3 P27361 1/20 0.36
MAPK8 P45983 2/20 0.36
MCHR1 Q99705 1/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
MET P08581 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333985 0.90 ADORA2A (0.38) MAPK1DYRK2CDK2CCNB2CCNE2
SCHEMBL31333789 0.89 DYRK2 (0.38) MAPK1DYRK2CDK2CCNB2CCNE2
SCHEMBL31334640 0.89 DYRK2 (0.38) MAPK1DYRK2CDK2CCNB2CCNE2
SCHEMBL31334770 0.88 MAPK8 (0.44) MAPK1DYRK2CDK2CCNB2CCNE2
SCHEMBL31334289 0.85 CDK9 (0.43) MAPK1CDK2CCNB2CCNE2CDK1
SCHEMBL31333247 0.85 MAPK1 (0.44) MAPK1DYRK2MCHR1CDK6
SCHEMBL31334347 0.84 DYRK2 (0.47) MAPK1DYRK2CDK2CCNB2CCNE2
SCHEMBL31333730 0.83 PDGFRB (0.37) PDGFRBPDGFRACDK2CCNB2CCNE2
SCHEMBL31334258 0.83 MAPK3 (0.39) MAPK1DYRK2CDK2CCNB2CCNE2
SCHEMBL31334938 0.82 MAPK8 (0.38) MAPK1DYRK2CDK2CCNA2MAPK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed