SCHEMBL31334146

SCHEMBL31334146

CC(C)(C)OC(=O)N1CCC(CCC(=O)N2CCC(Nc3ncc(Cl)c(-c4cccc(-c5ccccc5)c4)n3)CC2)CC1

nearest known ligand 0.49

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 7/20 0.49
MAPK9 P45984 7/20 0.49
MAPK10 P53779 4/20 0.49
JUN P05412 6/20 0.48
CDK2 P24941 6/20 0.48
MAPK1 P28482 10/20 0.47
CCNT1 O60563 1/20 0.45
USP30 Q70CQ3 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333767 0.93 MAPK8 (0.50) MAPK8MAPK9MAPK10JUNCDK2
SCHEMBL31333217 0.92 MAPK8 (0.54) MAPK8MAPK9MAPK10JUNCDK2
SCHEMBL31333971 0.90 MAPK1 (0.50) MAPK8MAPK9MAPK10JUNCDK2
SCHEMBL31333613 0.90 MAPK1 (0.55) MAPK8MAPK9MAPK10JUNCDK2
SCHEMBL31334404 0.90 MAPK1 (0.48) MAPK8MAPK9MAPK10JUNCDK2
SCHEMBL31334616 0.88 MAPK8 (0.51) MAPK8MAPK9MAPK10JUNCDK2
SCHEMBL31334306 0.86 MAPK1 (0.52) MAPK8MAPK9MAPK10JUNCDK2
SCHEMBL31334054 0.86 CCNT1 (0.52) MAPK8MAPK9MAPK10JUNCDK2
SCHEMBL31333657 0.85 MAPK1 (0.46) MAPK8MAPK9MAPK10JUNCDK2
SCHEMBL31334514 0.82 USP30 (0.52) CDK2MAPK1CCNT1USP30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed