SCHEMBL31334616

SCHEMBL31334616

CC(C)(C)OC(=O)N1CCC(C(=O)N2CCC(Nc3ncc(Cl)c(-c4cccc(-c5ccccc5)c4)n3)CC2)CC1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 7/20 0.51
MAPK9 P45984 7/20 0.51
MAPK10 P53779 5/20 0.51
USP30 Q70CQ3 3/20 0.48
MAPK1 P28482 5/20 0.48
JUN P05412 6/20 0.46
CDK2 P24941 6/20 0.46
FNTA P49354 1/20 0.46
FNTB P49356 1/20 0.46
CCNT1 O60563 1/20 0.46
CKS1B P61024 1/20 0.45
SKP1 P63208 1/20 0.45
SKP2 Q13309 1/20 0.45
STS P08842 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333217 0.96 MAPK8 (0.54) MAPK8MAPK9MAPK10USP30MAPK1
SCHEMBL31335014 0.94 CCNT1 (0.49) MAPK8MAPK9MAPK10MAPK1JUN
SCHEMBL31333428 0.93 MAPK8 (0.47) MAPK8MAPK9MAPK10USP30MAPK1
SCHEMBL31334190 0.91 USP30 (0.52) MAPK8MAPK9MAPK10USP30MAPK1
SCHEMBL31334054 0.89 CCNT1 (0.52) MAPK8MAPK9MAPK10USP30MAPK1
SCHEMBL31333767 0.89 MAPK8 (0.50) MAPK8MAPK9MAPK10USP30MAPK1
SCHEMBL31334146 0.88 MAPK8 (0.49) MAPK8MAPK9MAPK10USP30MAPK1
SCHEMBL31335038 0.88 CDK2 (0.54) MAPK8MAPK9MAPK10MAPK1JUN
SCHEMBL31334860 0.88 MAPK1 (0.56) MAPK8MAPK9MAPK10MAPK1JUN
SCHEMBL31334722 0.85 MAPK1 (0.53) MAPK8MAPK9MAPK10MAPK1JUN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed