SCHEMBL31334220

SCHEMBL31334220

O=C1CCC(N2Cc3cc(C4CCN(C5CCN(CCC(=O)N6CCC(Nc7ncc(Cl)c(-c8cccc(-c9ccccc9)c8)n7)CC6)CC5)CC4)ccc3C2=O)C(=O)N1

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
IKZF1 Q13422 4/20 0.50
MAPK1 P28482 2/20 0.47
IKZF2 Q9UKS7 13/20 0.47
CHRM2 P08172 1/20 0.46
CHRM4 P08173 1/20 0.46
CHRM5 P08912 1/20 0.46
CHRM1 P11229 1/20 0.46
CHRM3 P20309 1/20 0.46
METAP2 P50579 1/20 0.46
SLC6A3 Q01959 1/20 0.46
TMEM97 Q5BJF2 1/20 0.46
HRH3 Q9Y5N1 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333416 0.95 IKZF1 (0.52) IKZF1MAPK1IKZF2
SCHEMBL31334627 0.91 MAPK1 (0.41) IKZF1MAPK1CHRM2CHRM4CHRM5
SCHEMBL31333415 0.90 IKZF1 (0.53) IKZF1MAPK1IKZF2
SCHEMBL31334864 0.89 IKZF1 (0.52) IKZF1MAPK1IKZF2
SCHEMBL31333570 0.89 IKZF1 (0.49) IKZF1MAPK1IKZF2
SCHEMBL31333740 0.86 MAPK1 (0.44) IKZF1MAPK1
SCHEMBL31333897 0.86 MAPK1 (0.45) MAPK1
SCHEMBL31334006 0.86 MAPK1 (0.45) IKZF1MAPK1IKZF2
SCHEMBL31333787 0.85 IKZF1 (0.52) IKZF1IKZF2
SCHEMBL31333738 0.85 IKZF1 (0.51) IKZF1MAPK1IKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed