SCHEMBL31334453

SCHEMBL31334453

O=C1CCC(Nc2ccc(C3CCN(CCN4CCN(C(=O)C5CCCC(Nc6ncc(Cl)c(-c7cccc(-c8ccccc8)c7)n6)C5)CC4)CC3)cc2)C(=O)N1

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 19/20 0.41
CRBN Q96SW2 1/20 0.36
CDK12 Q9NYV4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333497 0.96 MAPK1 (0.41) MAPK1CRBNCDK12
SCHEMBL31333989 0.94 MAPK1 (0.46) MAPK1
SCHEMBL31334039 0.94 MAPK1 (0.41) MAPK1CRBN
SCHEMBL31334754 0.92 MAPK1 (0.45) MAPK1
SCHEMBL31333787 0.86 IKZF1 (0.52) CRBN
SCHEMBL31333262 0.86 MAPK1 (0.38) MAPK1CRBNCDK12
SCHEMBL31333897 0.84 MAPK1 (0.45) MAPK1
SCHEMBL31335016 0.82 MAPK1 (0.49) MAPK1
SCHEMBL31333339 0.82 MAPK1 (0.38) MAPK1CRBNCDK12
SCHEMBL31334521 0.82 MAPK1 (0.38) MAPK1CRBNCDK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed