SCHEMBL31334469

SCHEMBL31334469

CC(C)(C)OC(=O)N1CCN([C@H]2CCN(c3ccc(N)cc3F)C[C@H]2F)CC1

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 2/20 0.42
NR1H2 P55055 1/20 0.41
HRH3 Q9Y5N1 2/20 0.41
GPR119 Q8TDV5 8/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
DPP4 P27487 1/20 0.39
TP53 P04637 1/20 0.39
THRB P10828 1/20 0.39
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334894 1.00 USP30 (0.42) USP30NR1H2HRH3GPR119SMN1; SMN2
SCHEMBL31312885 0.89 USP30 (0.42) USP30HRH3GPR119SMN1; SMN2TP53
SCHEMBL31333878 0.86 LGMN (0.37) USP30NR1H2SMN1; SMN2LMNA
SCHEMBL24351663 0.86 HRH3 (0.51) USP30NR1H2HRH3GPR119SMN1; SMN2
SCHEMBL31334945 0.85 MAPT (0.50) DPP4THRBLMNA
SCHEMBL31333418 0.85 F10 (0.41) USP30
SCHEMBL660403 0.83 NR1H2 (0.53) NR1H2GPR119SMN1; SMN2TP53THRB
SCHEMBL29508938 0.83 NR1H2 (0.53) NR1H2GPR119SMN1; SMN2TP53THRB
SCHEMBL25366909 0.83 NR1H2 (0.46) USP30NR1H2HRH3GPR119SMN1; SMN2
SCHEMBL23783164 0.82 GPR119 (0.58) NR1H2GPR119SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed