SCHEMBL31334563

SCHEMBL31334563

CC(C)(C)OC(=O)N[C@H]1CC[C@H](Nc2ncc(F)c(-c3cccc(N4CCCCC4)c3)n2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CKS1B P61024 1/20 0.47
SKP1 P63208 1/20 0.47
SKP2 Q13309 1/20 0.47
MAPK1 P28482 3/20 0.46
DYRK2 Q92630 5/20 0.42
SYK P43405 3/20 0.40
CDK4 P11802 2/20 0.39
CCND1 P24385 2/20 0.39
CCND3 P30281 2/20 0.39
CDK6 Q00534 2/20 0.39
ALK Q9UM73 1/20 0.39
CCNB2 O95067 1/20 0.39
CCNE2 O96020 1/20 0.39
CDK1 P06493 1/20 0.39
CCNB1 P14635 1/20 0.39
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
CDK5 Q00535 1/20 0.39
CDK5R1 Q15078 1/20 0.39
CCNB3 Q8WWL7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334264 0.92 MAPK1 (0.52) CKS1BSKP1SKP2MAPK1DYRK2
SCHEMBL31333654 0.89 DYRK2 (0.49) CKS1BSKP1SKP2MAPK1DYRK2
SCHEMBL31334631 0.88 SYK (0.43) CKS1BSKP1SKP2DYRK2SYK
SCHEMBL31334316 0.87 MAPK1 (0.46) CKS1BSKP1SKP2MAPK1DYRK2
SCHEMBL31333206 0.86 CKS1B (0.51) CKS1BSKP1SKP2MAPK1DYRK2
SCHEMBL31333648 0.85 MAPK1 (0.48) CKS1BSKP1SKP2MAPK1DYRK2
SCHEMBL31333524 0.85 SYK (0.42) MAPK1DYRK2SYKCDK4CCND1
SCHEMBL31333445 0.84 MAPK1 (0.47) CKS1BSKP1SKP2MAPK1DYRK2
SCHEMBL31333816 0.84 MAPK1 (0.47) CKS1BSKP1SKP2MAPK1DYRK2
SCHEMBL31334031 0.83 MAPK8 (0.49) DYRK2SYKCDK4CDK6CCNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed