SCHEMBL31334649

SCHEMBL31334649

O=C1CCC(N2Cc3c(OC4CCN(C5CCCN(CC(=O)N6CCC(Nc7ncc(Cl)c(-c8cccc(-c9ccc(F)cc9)c8)n7)CC6)C5)CC4)cccc3C2=O)C(=O)N1

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 7/20 0.42
CDK12 Q9NYV4 1/20 0.42
IKZF3 Q9UKT9 5/20 0.41
MAPK1 P28482 13/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334006 0.87 MAPK1 (0.45) CRBNMAPK1
SCHEMBL31333740 0.80 MAPK1 (0.44) MAPK1
SCHEMBL31333319 0.80 MAPK1 (0.40) CRBNCDK12MAPK1
SCHEMBL31334627 0.77 MAPK1 (0.41) MAPK1
SCHEMBL31333659 0.76 MAPK1 (0.44) MAPK1
SCHEMBL31333416 0.76 IKZF1 (0.52) MAPK1
SCHEMBL31334935 0.76 MAPK1 (0.44) CRBNMAPK1
SCHEMBL31333283 0.75 CRBN (0.50) CRBNCDK12IKZF3MAPK1
SCHEMBL31333647 0.74 MAPK1 (0.44) MAPK1
SCHEMBL31333199 0.73 MAPK1 (0.42) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed