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SCHEMBL31334674

SCHEMBL31334674

Cn1c(=O)n(C2CCC(=O)NC2=O)c2ccc(C3CCN(CCN4CCC(C(=O)N5CCC[C@H](Nc6ncc(Cl)c(-c7cccc(-c8ccccc8)c7)n6)C5)CC4)CC3)cc21

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 4/20 0.39
▸ CDK12 Q9NYV4 2/20 0.39
▸ MAPK1 P28482 11/20 0.39
▸ JUN P05412 4/20 0.38
▸ MAPK8 P45983 4/20 0.38
▸ MAPK9 P45984 4/20 0.38
▸ MAPK10 P53779 4/20 0.38
▸ CDK2 P24941 3/20 0.38
▸ DDB1 Q16531 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334794 0.93 MAPK1 (0.41) CRBNMAPK1JUNMAPK8MAPK9
SCHEMBL31333262 0.92 MAPK1 (0.38) CRBNCDK12MAPK1DDB1
SCHEMBL31334680 0.90 MAPK1 (0.41) CRBNCDK12MAPK1JUNMAPK8
SCHEMBL31334334 0.90 MAPK1 (0.41) CRBNCDK12MAPK1JUNMAPK8
SCHEMBL31333715 0.89 MAPK1 (0.44) MAPK1JUNMAPK8MAPK9MAPK10
SCHEMBL31333312 0.88 MAPK1 (0.41) MAPK1
SCHEMBL31335057 0.88 MAPK1 (0.38) CRBNCDK12MAPK1DDB1
SCHEMBL31334521 0.88 MAPK1 (0.38) CRBNCDK12MAPK1DDB1
SCHEMBL31333339 0.88 MAPK1 (0.38) CRBNCDK12MAPK1DDB1
SCHEMBL31333237 0.87 MAPK1 (0.42) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 — — EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 — — WO disclosed