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SCHEMBL31334680

SCHEMBL31334680

Cn1c(=O)n(C2CCC(=O)NC2=O)c2ccc(C3CCN(CC4CCN(CC(=O)N5CCC[C@H](Nc6ncc(Cl)c(-c7cccc(-c8ccccc8)c7)n6)C5)CC4)CC3)cc21

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 17/20 0.41
▸ CRBN Q96SW2 1/20 0.38
▸ CDK12 Q9NYV4 1/20 0.38
▸ JUN P05412 2/20 0.37
▸ CDK2 P24941 2/20 0.37
▸ MAPK8 P45983 2/20 0.37
▸ MAPK9 P45984 2/20 0.37
▸ MAPK10 P53779 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334334 0.94 MAPK1 (0.41) MAPK1CRBNCDK12JUNCDK2
SCHEMBL31333626 0.94 MAPK1 (0.44) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31334674 0.90 CRBN (0.39) MAPK1CRBNCDK12JUNCDK2
SCHEMBL31334361 0.89 MAPK1 (0.41) MAPK1
SCHEMBL31333312 0.89 MAPK1 (0.41) MAPK1
SCHEMBL31333715 0.88 MAPK1 (0.44) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31333237 0.87 MAPK1 (0.42) MAPK1
SCHEMBL31334665 0.87 MAPK1 (0.44) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31334402 0.87 MAPK1 (0.37) MAPK1CRBN
SCHEMBL31333262 0.85 MAPK1 (0.38) MAPK1CRBNCDK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 — — EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 — — WO disclosed