SCHEMBL31334716

SCHEMBL31334716

O=C1CCC(Nc2ccc(C3CCN(C4CCC(NC(=O)[C@H]5CC[C@H](Nc6ncc(F)c(-c7cccc(-c8ccccc8)c7)n6)CC5)CC4)CC3)c(F)c2)C(=O)N1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 11/20 0.35
CRBN Q96SW2 11/20 0.35
MAPK1 P28482 1/20 0.34
CSF1R P07333 5/20 0.34
CDK4 P11802 5/20 0.34
CDK6 Q00534 5/20 0.34
PIK3CD O00329 3/20 0.34
CCNA2 P20248 2/20 0.33
CDK2 P24941 2/20 0.33
CDK9 P50750 2/20 0.33
CCNT1 O60563 1/20 0.33
CCNK O75909 1/20 0.32
CDK7 P50613 1/20 0.32
CCNH P51946 1/20 0.32
CDK5 Q00535 1/20 0.32
CDK5R1 Q15078 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334619 1.00 DDB1 (0.35) DDB1CRBNMAPK1CSF1RCDK4
SCHEMBL31333502 0.94 DDB1 (0.34) DDB1CRBNMAPK1CSF1RCDK4
SCHEMBL31334765 0.94 DDB1 (0.34) DDB1CRBNMAPK1CSF1RCDK4
SCHEMBL31334827 0.92 MAPK1 (0.34) DDB1CRBNMAPK1CSF1RCDK4
SCHEMBL31333381 0.92 MAPK1 (0.34) DDB1CRBNMAPK1CSF1RCDK4
SCHEMBL31334577 0.92 MAPK1 (0.34) DDB1CRBNMAPK1CSF1RCDK4
SCHEMBL31333829 0.92 MAPK1 (0.34) DDB1CRBNMAPK1CSF1RCDK4
SCHEMBL31334009 0.92 MAPK1 (0.34) DDB1CRBNMAPK1CSF1RCDK4
SCHEMBL31333967 0.92 SYK (0.34) DDB1CRBNMAPK1CSF1RCDK4
SCHEMBL31333441 0.92 SYK (0.34) DDB1CRBNMAPK1CSF1RCDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed