Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.90 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8293662 | 1.00 | SMN1; SMN2 (0.90) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 | |
| SCHEMBL10102476 | 0.85 | HDAC3 (0.75) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 | |
| SCHEMBL13299860 | 0.85 | HDAC3 (0.75) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 | |
| Hydrochloric Acid SCHEMBL3128502 | 0.83 | HDAC3 (0.73) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 | |
| SCHEMBL24795619 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 | |
| SCHEMBL14786047 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 | |
| SCHEMBL9095557 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 | |
| SCHEMBL4306915 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 | |
| SCHEMBL9941474 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 | |
| SCHEMBL20340796 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1HDAC3HDAC1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065461-A1 | TRI-PEPTIDE INHIBITORS OF SERINE ELASTASES | ACCUTHERA, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010065461-A1 | TRI-PEPTIDE INHIBITORS OF SERINE ELASTASES | ACCUTHERA, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20090156509-A1 | Tri-peptide Inhibitors of Serine Elastases | ACCUTHERA, INC. (US) | 2009-06-18 | — | — | US | disclosed |
| US-20090156509-A1 | Tri-peptide Inhibitors of Serine Elastases | ACCUTHERA, INC. (US) | 2009-06-18 | — | — | US | disclosed |
| US-20090156509-A1 | Tri-peptide Inhibitors of Serine Elastases | ACCUTHERA, INC. (US) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156509-A1 | Tri-peptide Inhibitors of Serine Elastases | SCTR, CTRC, SERPINB1 | SMN1; SMN2 2130/4885ALDH1A1 4437/4885HDAC3 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.