SCHEMBL31334992

SCHEMBL31334992

O=C(c1cccc(-c2nc(NC3CCCCC3)ncc2F)c1)N1CC[C@H](O)C1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CCNK O75909 6/20 0.49
CDK12 Q9NYV4 6/20 0.49
ATR Q13535 1/20 0.47
DYRK2 Q92630 8/20 0.47
LRRK2 Q5S007 1/20 0.44
CDK2 P24941 4/20 0.44
CDK7 P50613 4/20 0.44
CCNH P51946 4/20 0.44
MNAT1 P51948 4/20 0.44
CCNT1 O60563 1/20 0.44
CCNE1 P24864 1/20 0.44
CDK9 P50750 1/20 0.44
CDK4 P11802 1/20 0.44
CDK6 Q00534 1/20 0.44
CCNA2 P20248 3/20 0.43
VNN1 O95497 1/20 0.42
EPHX2 P34913 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334503 0.91 DYRK2 (0.49) CCNKCDK12ATRDYRK2LRRK2
SCHEMBL31334011 0.91 DYRK2 (0.49) CCNKCDK12ATRDYRK2LRRK2
SCHEMBL31334870 0.91 ATR (0.48) CCNKCDK12ATRDYRK2LRRK2
SCHEMBL31333850 0.91 ATR (0.47) CCNKCDK12ATRDYRK2LRRK2
SCHEMBL31333517 0.91 ATR (0.47) CCNKCDK12ATRDYRK2LRRK2
SCHEMBL31335052 0.91 ATR (0.47) CCNKCDK12ATRDYRK2LRRK2
SCHEMBL31334370 0.90 ATR (0.47) CCNKCDK12ATRDYRK2LRRK2
SCHEMBL31334061 0.90 ATR (0.45) CCNKCDK12ATRDYRK2LRRK2
SCHEMBL31333202 0.87 DYRK2 (0.48) CCNKCDK12DYRK2LRRK2CDK2
SCHEMBL31333642 0.85 DYRK2 (0.45) CCNKCDK12ATRDYRK2LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed