Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CCNK | O75909 | 2/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.39 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31335825 | 0.86 | NR1H2 (0.53) | KDM4EJAK3JAK2JAK1TYK2 | |
| SCHEMBL31335769 | 0.83 | JAK3 (0.44) | KDM4EJAK3JAK2JAK1TYK2 | |
| SCHEMBL31335547 | 0.83 | JAK2 (0.44) | KDM4EJAK3JAK2JAK1TYK2 | |
| SCHEMBL25212858 | 0.79 | FLT3 (0.41) | KDM4EJAK3JAK2JAK1TYK2 | |
| SCHEMBL30377587 | 0.79 | FLT3 (0.41) | KDM4EJAK3JAK2JAK1TYK2 | |
| SCHEMBL31335904 | 0.76 | MELK (0.50) | ITK | |
| Hydrochloric Acid SCHEMBL31335956 | 0.76 | ITGB3 (0.50) | — | |
| SCHEMBL20873104 | 0.74 | NAMPT (0.47) | KDM4ENPC1RAB9ATMPRSS2LMNA | |
| SCHEMBL20873101 | 0.74 | NAMPT (0.47) | KDM4ENPC1RAB9ATMPRSS2LMNA | |
| SCHEMBL31176413 | 0.72 | JAK3 (0.45) | JAK3JAK2JAK1TYK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720038-A1 | (HETERO)ARYL-CARBONYL-HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PMS2 FOR CANCER AND DEGENERATIVE ILLNESSES | Neophore Limited (GB) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246496-A1 | (HETERO)ARYL-CARBONYL-HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PMS2 FOR CANCER AND DEGENERATIVE ILLNESSES | Neophore Limited (GB) | 2024-12-05 | — | — | WO | disclosed |