Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29764171 | 1.00 | KDM4E (0.48) | KDM4EPOLBGPR119HTTTRPV1 | |
| SCHEMBL23602021 | 1.00 | KDM4E (0.48) | KDM4EPOLBGPR119HTTTRPV1 | |
| SCHEMBL28809309 | 0.84 | ALDH1A1 (0.45) | KDM4EHTTTRPV1ALDH1A1HCRTR1 | |
| SCHEMBL23602022 | 0.84 | MAP4K4 (0.53) | KDM4EPOLBGPR119HTTTRPV1 | |
| SCHEMBL29144191 | 0.79 | AR (0.44) | GPR119 | |
| SCHEMBL23133940 | 0.79 | AR (0.44) | GPR119 | |
| SCHEMBL29144194 | 0.79 | AR (0.44) | GPR119 | |
| SCHEMBL29728622 | 0.79 | AR (0.44) | GPR119 | |
| SCHEMBL11355918 | 0.78 | GPR119 (0.52) | GPR119TRPV1MAP4K4 | |
| SCHEMBL11363869 | 0.75 | GPR119 (0.50) | GPR119TRPV1MAP4K4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081524-B1 | SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2025-01-29 | — | — | EP | disclosed |