SCHEMBL31336618

SCHEMBL31336618

C=CC(=O)Nc1cnc2c(cnn2Cc2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 2/20 0.49
FGFR1 P11362 4/20 0.44
FGFR4 P22455 4/20 0.44
TEAD1 P28347 2/20 0.44
NR3C1 P04150 8/20 0.41
JAK3 P52333 2/20 0.41
JAK2 O60674 1/20 0.40
GSTO1 P78417 1/20 0.40
F13A1 P00488 1/20 0.39
TGM1 P22735 1/20 0.39
ERBB2 P04626 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26220306 1.00 TGM2 (0.49) TGM2FGFR1FGFR4TEAD1NR3C1
SCHEMBL26220308 0.84 TGM2 (0.53) TGM2FGFR1FGFR4TEAD1GSTO1
SCHEMBL26220303 0.84 FGFR1 (0.56) TGM2FGFR1FGFR4TEAD1NR3C1
SCHEMBL31336552 0.84 FGFR1 (0.56) TGM2FGFR1FGFR4TEAD1NR3C1
SCHEMBL31336744 0.83 TGM2 (0.53) TGM2FGFR1FGFR4NR3C1GSTO1
SCHEMBL26220771 0.83 TGM2 (0.53) TGM2FGFR1FGFR4NR3C1GSTO1
SCHEMBL25386892 0.82 JAK3 (0.47) TGM2FGFR1FGFR4TEAD1NR3C1
SCHEMBL26220505 0.82 FGFR1 (0.56) TGM2FGFR1FGFR4TEAD1GSTO1
SCHEMBL31336538 0.82 TGM2 (0.43) TGM2FGFR1FGFR4TEAD1NR3C1
SCHEMBL26220501 0.82 TGM2 (0.43) TGM2FGFR1FGFR4TEAD1NR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250171451-A1 NOVEL HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2025-05-29 US disclosed
EP-4488276-A1 NOVEL HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME Samjin Pharmaceutical Co., Ltd. (KR) 2025-01-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250171451-A1 NOVEL HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME CYP4A11, CYP11B2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 TGM2 4139/4885FGFR1 1095/4885FGFR4 1563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.