SCHEMBL31336683

SCHEMBL31336683

Cc1c(-c2ccc(F)cn2)c(C(=O)O)nn1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 8/20 0.43
POLB P06746 3/20 0.37
KMT2A Q03164 2/20 0.37
KDM4E B2RXH2 2/20 0.37
LMNA P02545 2/20 0.37
GAA P10253 2/20 0.37
RAB9A P51151 1/20 0.37
GABRA5 P31644 1/20 0.36
NOTUM Q6P988 1/20 0.35
CSNK1D P48730 1/20 0.35
MAPK14 Q16539 1/20 0.35
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
ALDH1A1 P00352 1/20 0.34
APOBEC3A P31941 1/20 0.34
GFER P55789 1/20 0.34
DHODH Q02127 1/20 0.34
P4HA1 P13674 1/20 0.34
P4HTM Q9NXG6 1/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31336654 0.91 GRM5 (0.38) GRM5KMT2AGABRA5NOTUMCSNK1D
SCHEMBL19207031 0.82 HCRTR1 (0.42) GRM5POLBKMT2AKDM4ELMNA
SCHEMBL31336798 0.82 GABRA1 (0.40) GRM5POLBKMT2AKDM4ELMNA
SCHEMBL31336769 0.81 JMJD6 (0.39) GRM5POLBKDM4EGAAALDH1A1
SCHEMBL31336740 0.81 POLB (0.50) POLBKDM4ELMNAGAARAB9A
SCHEMBL31372596 0.79 GABRA5 (0.40) GRM5KMT2AGABRA5NOTUMCSNK1D
SCHEMBL31336692 0.75 KDM4E (0.39) POLBKMT2AKDM4EGAARAB9A
SCHEMBL31336880 0.75 PDE2A (0.39) GRM5LMNACSNK1DMAPK14ALDH1A1
SCHEMBL23147354 0.74 GRM5 (0.41) GRM5POLBKMT2AKDM4ELMNA
SCHEMBL19207117 0.74 CSNK1D (0.44) CSNK1DMAPK14DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106499-A1 OREXIN RECEPTOR ANTAGONISTS: 2-AZABICYCLIC COMPOUNDS BIAL - PORTELA & CA., S.A. (PT) 2026-05-21 WO claimed
EP-4688154-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS BIAL - Portela & Ca., S.A. (PT) 2026-02-11 EP claimed
EP-4688155-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS Bial-Portela & CA, S.A. (PT) 2026-02-11 EP claimed
WO-2025023851-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS BIAL - PORTELA & CA., S.A. (PT) 2025-01-30 WO claimed
WO-2025023852-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS BIAL - PORTELA & CA., S.A. (PT) 2025-01-30 WO claimed
WO-2026106499-A1 OREXIN RECEPTOR ANTAGONISTS: 2-AZABICYCLIC COMPOUNDS BIAL - PORTELA & CA., S.A. (PT) 2026-05-21 WO disclosed
EP-4688154-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS BIAL - Portela & Ca., S.A. (PT) 2026-02-11 EP disclosed
EP-4688155-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS Bial-Portela & CA, S.A. (PT) 2026-02-11 EP disclosed
WO-2025023851-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS BIAL - PORTELA & CA., S.A. (PT) 2025-01-30 WO disclosed
WO-2025023852-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS BIAL - PORTELA & CA., S.A. (PT) 2025-01-30 WO disclosed