Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134403 | 0.86 | TP53 (0.57) | L3MBTL1HTTGAATDP1ALDH1A1 | |
| SCHEMBL27480522 | 0.82 | HTT (0.71) | L3MBTL1HTTGAAMEN1KMT2A | |
| SCHEMBL12206732 | 0.79 | KMT2A (0.50) | L3MBTL1HTTGAAMEN1KMT2A | |
| SCHEMBL8921640 | 0.79 | RAB9A (0.45) | HTTMEN1KMT2APOLBTDP1 | |
| SCHEMBL1726189 | 0.78 | HRH2 (0.45) | L3MBTL1HTTGAAMEN1KMT2A | |
| SCHEMBL12233216 | 0.78 | RAB9A (0.51) | L3MBTL1HTTMEN1KMT2APOLB | |
| SCHEMBL5407237 | 0.78 | MEN1 (0.52) | L3MBTL1HTTMEN1KMT2APOLB | |
| SCHEMBL31224515 | 0.78 | HTT (0.54) | L3MBTL1HTTGAAMEN1KMT2A | |
| SCHEMBL5675565 | 0.77 | RAB9A (0.47) | HTTMEN1KMT2APOLBKIT | |
| SCHEMBL22597880 | 0.77 | RAB9A (0.47) | HTTGAAMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045451-A1 | PYRROLOPYRIMIDINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-22 | — | — | WO | disclosed |
| EP-2162454-A1 | IMIDAZOPYRIDINE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150799-A1 | IMIDAZOPYRIDINE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |