Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3133674 | 0.86 | L3MBTL1 (0.52) | TDP1ALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL22852237 | 0.82 | MAPK1 (0.53) | TP53TDP1CHRM1CHRM2L3MBTL1 | |
| SCHEMBL3636863 | 0.78 | TP53 (0.44) | TP53TDP1CHRM1CHRM2ALDH1A1 | |
| SCHEMBL5225927 | 0.77 | CHRM1 (0.46) | TP53TDP1CHRM1CHRM2ALDH1A1 | |
| SCHEMBL310402 | 0.77 | ALDH1A1 (0.51) | TP53TDP1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14344122 | 0.75 | ALDH1A1 (0.64) | TP53TDP1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5249314 | 0.75 | GPR119 (0.45) | TP53TDP1CHRM1CHRM2HTT | |
| SCHEMBL704010 | 0.75 | RAB9A (0.51) | CHRM1CHRM2ALDH1A1L3MBTL1GPR119 | |
| SCHEMBL794087 | 0.74 | RAB9A (0.50) | CHRM1CHRM2ALDH1A1L3MBTL1GPR119 | |
| SCHEMBL8262844 | 0.74 | RAB9A (0.50) | CHRM1CHRM2ALDH1A1L3MBTL1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045451-A1 | PYRROLOPYRIMIDINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-22 | — | — | WO | disclosed |
| EP-2162454-A1 | IMIDAZOPYRIDINE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150799-A1 | IMIDAZOPYRIDINE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |