Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20745512 | 0.84 | LMNA (0.54) | LMNAKDM4EMAPTALDH1A1NPSR1 | |
| SCHEMBL31338390 | 0.80 | LMNA (0.50) | LMNAKDM4EMAPTALDH1A1NPSR1 | |
| SCHEMBL20745289 | 0.79 | LMNA (0.58) | LMNAKDM4EMAPTALDH1A1NPSR1 | |
| SCHEMBL31338386 | 0.77 | LMNA (0.56) | LMNAKDM4EMAPTALDH1A1NPSR1 | |
| SCHEMBL20745455 | 0.75 | KDM4E (0.52) | LMNAKDM4EMAPTALDH1A1NPSR1 | |
| SCHEMBL20745593 | 0.72 | LMNA (0.45) | LMNAKDM4EMAPTALDH1A1NPSR1 | |
| SCHEMBL20745518 | 0.71 | ALDH1A1 (0.47) | LMNAKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL20745269 | 0.71 | KDM4E (0.57) | LMNAKDM4EMAPTALDH1A1NPSR1 | |
| SCHEMBL20745645 | 0.70 | ALDH1A1 (0.44) | LMNAKDM4EMAPTALDH1A1NPSR1 | |
| SCHEMBL20745714 | 0.69 | LMNA (0.42) | LMNAKDM4EMAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739658-A1 | SYNTHESIS OF PYRUVATE KINASE ACTIVATORS | Agios Pharmaceuticals, Inc. (US) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025010390-A1 | SYNTHESIS OF PYRUVATE KINASE ACTIVATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2025-01-09 | — | — | WO | disclosed |