Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 4/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.33 |
| ▸ | RET | P07949 | 3/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30447567 | 1.00 | MAP4K4 (0.35) | MAP4K4EIF2AK4PDE2ASCN9AKDM1A | |
| SCHEMBL30447801 | 0.89 | JAK1 (0.36) | MAP4K4EIF2AK4KDM1AAURKAPDPK1 | |
| SCHEMBL31339782 | 0.89 | JAK1 (0.36) | MAP4K4EIF2AK4KDM1AAURKAPDPK1 | |
| SCHEMBL30447302 | 0.86 | ATM (0.33) | MAP4K4EIF2AK4RETHDAC1HDAC3 | |
| SCHEMBL25430094 | 0.85 | DRD2 (0.34) | EIF2AK4PDE2AKDM1ARETCKS1B | |
| SCHEMBL25342939 | 0.78 | MAP4K4 (0.38) | MAP4K4EIF2AK4KDM1AAURKAPDPK1 | |
| SCHEMBL30447631 | 0.78 | MAP4K4 (0.38) | MAP4K4EIF2AK4KDM1AAURKAPDPK1 | |
| SCHEMBL25429189 | 0.74 | P2RX3 (0.34) | HDAC1HDAC3HDAC2 | |
| SCHEMBL25431643 | 0.74 | NTRK1 (0.43) | SCN9ALCK | |
| SCHEMBL25429763 | 0.74 | JAK1 (0.34) | EIF2AK4KDM1AAURKBRETCKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119365192-A | Heteroaryl compounds as HPK1 inhibitors and methods of use thereof | 深圳市原力深湾创新药有限公司 | 2025-01-24 | — | — | CN | disclosed |