Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16685622 | 0.73 | NPC1 (0.48) | KMT2ALMNAPOLBCYP1A2CYP2C9 | |
| SCHEMBL3145566 | 0.73 | KMT2A (0.51) | KMT2AKDM4ELMNACYP1A2CYP3A4 | |
| SCHEMBL16914145 | 0.72 | NPC1 (0.37) | KMT2AKDM4ELMNAPOLBCYP1A2 | |
| SCHEMBL16914247 | 0.72 | ALDH1A1 (0.36) | KMT2AKDM4ELMNAPOLBCYP1A2 | |
| SCHEMBL16685593 | 0.71 | ABCB1 (0.42) | KMT2AKDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL16913997 | 0.71 | NPC1 (0.36) | KMT2AKDM4ELMNAPOLBCYP1A2 | |
| SCHEMBL31340962 | 0.71 | KMT2A (0.47) | KMT2AJAK2JAK3 | |
| SCHEMBL16685800 | 0.71 | SLC6A2 (0.41) | NPC1RAB9AGAACSF1RNTRK1 | |
| SCHEMBL27196854 | 0.70 | KMT2A (0.60) | KMT2AKDM4ELMNAPOLBGAA | |
| SCHEMBL16914178 | 0.69 | KDM4E (0.35) | KMT2AKDM4ELMNAPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049247-A1 | 5,6-CORE SILACYCLE BASED INHIBITORS OF DNA-DEPENDENT PROTEIN KINASE AND COMPOSITIONS AND APPLICATION IN GENE EDITING | JUNO THERAPEUTICS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |