Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | PLD2 | O14939 | 8/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 8/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.45 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | AKT2 | P31751 | 2/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434705 | 0.88 | USP2 (0.57) | USP2ALDH1A1LMNASIRT2PLD2 | |
| SCHEMBL13153966 | 0.85 | ALDH1A1 (0.57) | USP2ALDH1A1LMNAPLD2PLD1 | |
| SCHEMBL4439012 | 0.85 | USP2 (0.63) | USP2ALDH1A1LMNAPLD2PLD1 | |
| Hydrochloric Acid SCHEMBL29848399 | 0.84 | ALDH1A1 (0.56) | USP2ALDH1A1LMNAPLD2PLD1 | |
| SCHEMBL6840371 | 0.84 | USP2 (0.53) | USP2ALDH1A1LMNASIRT2PLD2 | |
| SCHEMBL13899718 | 0.83 | USP2 (0.52) | USP2ALDH1A1LMNAPLD2PLD1 | |
| SCHEMBL30870639 | 0.82 | SIRT2 (0.49) | USP2ALDH1A1LMNASIRT2PLD2 | |
| SCHEMBL14008572 | 0.82 | YEATS4 (0.66) | USP2ALDH1A1LMNAPLD2PLD1 | |
| Trifluoroacetic Acid SCHEMBL4434600 | 0.81 | USP2 (0.56) | USP2ALDH1A1LMNAPLD2PLD1 | |
| SCHEMBL20529124 | 0.81 | B3GNT2 (0.52) | USP2ALDH1A1LMNAPLD2PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-B1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | HOFFMANN LA ROCHE (CH) | 2010-07-07 | — | — | EP | disclosed |
| EP-1440976-B1 | Modified aminoacids, pharmaceuticals containing these compounds and method for their production | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-07-23 | — | — | EP | disclosed |