Aristophenone A

Aristophenone A

SCHEMBL31345818

CC(C)=CC[C@@H]1C[C@]2(CC=C(C)C)C(=O)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)=C2O)C1(C)C

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 8/20 0.69
HDAC11 Q96DB2 2/20 0.69
PTGES O14684 1/20 0.58
KAT2B Q92831 1/20 0.58
HDAC8 Q9BY41 1/20 0.58
POLL Q9UGP5 8/20 0.56
STAT1 P42224 1/20 0.56
MET P08581 3/20 0.54
SIRT2 Q8IXJ6 3/20 0.51
SIRT1 Q96EB6 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guttiferone O SCHEMBL31345820 0.93 MET (0.61) EP300HDAC11PTGESKAT2BHDAC8
Guttiferone B SCHEMBL31345806 0.92 MET (0.65) EP300HDAC11PTGESKAT2BHDAC8
SCHEMBL23815576 0.89 EP300 (0.61) EP300HDAC11PTGESKAT2BHDAC8
SCHEMBL23815578 0.89 EP300 (0.61) EP300HDAC11PTGESKAT2BHDAC8
6-Epi-Guttiferone J SCHEMBL31292810 0.89 POLL (0.72) EP300HDAC11PTGESPOLLSTAT1
Guttiferone A SCHEMBL12634388 0.89 POLL (0.72) EP300HDAC11PTGESPOLLSTAT1
Guttiferone K SCHEMBL31345834 0.89 POLL (0.72) EP300HDAC11PTGESPOLLSTAT1
Guttiferone K SCHEMBL717385 0.89 POLL (0.72) EP300HDAC11PTGESPOLLSTAT1
Guttiferone F SCHEMBL25049796 0.88 EP300 (0.75) EP300HDAC11PTGESKAT2BHDAC8
Guttiferone F SCHEMBL23607580 0.88 EP300 (0.75) EP300HDAC11PTGESKAT2BHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025024478-A1 COMPOSITIONS FOR THE MODULATION OF TASTE IXORA SCIENTIFIC INC. (US) 2025-01-30 WO claimed
WO-2025024478-A1 COMPOSITIONS FOR THE MODULATION OF TASTE IXORA SCIENTIFIC INC. (US) 2025-01-30 WO disclosed