Guttiferone K

Guttiferone K

SCHEMBL31345834

CC(C)=CCC[C@@]1(C)[C@H](CC=C(C)C)C[C@]2(CC=C(C)C)C(=O)[C@@]1(CC=C(C)C)C(=O)C(C(=O)c1ccc(O)c(O)c1)=C2O

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ POLL Q9UGP5 7/20 0.72
▸ STAT1 P42224 1/20 0.72
▸ MET P08581 7/20 0.69
▸ SIRT2 Q8IXJ6 4/20 0.66
▸ SIRT1 Q96EB6 4/20 0.66
▸ EP300 Q09472 3/20 0.56
▸ HDAC11 Q96DB2 1/20 0.56
▸ PTGES O14684 2/20 0.50
▸ NR1I2 O75469 1/20 0.50
▸ CYP3A4 P08684 1/20 0.50
▸ DLAT P10515 1/20 0.50
▸ MAPT P10636 1/20 0.50
▸ SLC6A2 P23975 1/20 0.50
▸ SLC6A4 P31645 1/20 0.50
▸ SLC6A3 Q01959 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6-Epi-Guttiferone J SCHEMBL31292810 1.00 POLL (0.72) POLLSTAT1METSIRT2SIRT1
Guttiferone K SCHEMBL717385 1.00 POLL (0.72) POLLSTAT1METSIRT2SIRT1
Guttiferone A SCHEMBL12634388 1.00 POLL (0.72) POLLSTAT1METSIRT2SIRT1
Guttiferone P SCHEMBL31345812 0.96 MET (0.74) POLLSTAT1METSIRT2SIRT1
SCHEMBL21710405 0.96 POLL (0.68) POLLSTAT1METSIRT2SIRT1
Guttiferone I SCHEMBL31238109 0.95 MET (0.77) POLLSTAT1METSIRT2SIRT1
Aristophenone A SCHEMBL31345818 0.89 EP300 (0.69) POLLSTAT1METSIRT2SIRT1
Guttiferone L SCHEMBL31345836 0.88 POLL (0.60) POLLSTAT1METSIRT2SIRT1
Guttiferone O SCHEMBL31345820 0.87 MET (0.61) POLLSTAT1METSIRT2SIRT1
Guttiferone B SCHEMBL31345806 0.86 MET (0.65) POLLSTAT1METSIRT2SIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025024478-A1 COMPOSITIONS FOR THE MODULATION OF TASTE IXORA SCIENTIFIC INC. (US) 2025-01-30 — — WO claimed
WO-2025024478-A1 COMPOSITIONS FOR THE MODULATION OF TASTE IXORA SCIENTIFIC INC. (US) 2025-01-30 — — WO disclosed
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