SCHEMBL31346016

SCHEMBL31346016

O=c1[nH]c(-c2cccc(C3Cc4cc(Cl)cc(Cl)c4O3)n2)no1

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.37
IP6K1 Q92551 1/20 0.33
MDM2 Q00987 4/20 0.32
EZH2 Q15910 1/20 0.32
FTO Q9C0B1 1/20 0.32
GRIK1 P39086 1/20 0.31
PARP1 P09874 1/20 0.31
SLC6A2 P23975 2/20 0.30
PRKAG1 P54619 1/20 0.30
PRKAA2 P54646 1/20 0.30
PRKAB1 Q9Y478 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31346150 0.81 PDE5A (0.37) KMOIP6K1MDM2FTOPARP1
SCHEMBL31346153 0.81 PDE5A (0.37) KMOIP6K1MDM2FTOPARP1
SCHEMBL31346035 0.80 SLC6A2 (0.36) KMOMDM2PARP1SLC6A2
SCHEMBL31346141 0.75 EZH2 (0.38) EZH2
SCHEMBL31346159 0.73 RORC (0.35) MDM2PARP1
SCHEMBL31346157 0.73 RORC (0.35) MDM2PARP1
SCHEMBL31346161 0.73 RORC (0.35) MDM2PARP1
SCHEMBL31346087 0.72 EZH2 (0.36) EZH2
SCHEMBL31346107 0.69 CNR1 (0.37) KMOIP6K1MDM2SLC6A2
SCHEMBL31346081 0.69 EZH2 (0.33) EZH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 EP disclosed
WO-2024239000-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST ENVEDA THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed