SCHEMBL31346019

SCHEMBL31346019

O=c1oc(-c2cccc(C3Cc4cc(C(F)(F)F)ccc4O3)c2)ns1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSMB8 P28062 9/20 0.44
PSMB11 A5LHX3 1/20 0.38
PSMD11 O00231 1/20 0.38
PSMD12 O00232 1/20 0.38
PSMD14 O00487 1/20 0.38
PSMA7 O14818 1/20 0.38
PSMD3 O43242 1/20 0.38
PSMC3 P17980 1/20 0.38
PSMB1 P20618 1/20 0.38
PSMA1 P25786 1/20 0.38
PSMA2 P25787 1/20 0.38
PSMA3 P25788 1/20 0.38
PSMA4 P25789 1/20 0.38
PSMB9 P28065 1/20 0.38
PSMA5 P28066 1/20 0.38
PSMB4 P28070 1/20 0.38
PSMB6 P28072 1/20 0.38
PSMB5 P28074 1/20 0.38
PSMC2 P35998 1/20 0.38
PSMB10 P40306 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1780464 0.76 PSMB8 (0.63) PSMB8PSMB11PSMD11PSMD12PSMD14
SCHEMBL31346041 0.76 FFAR1 (0.38) FFAR1NOTUMCYP19A1
SCHEMBL31346059 0.76 FFAR1 (0.38) FFAR1NOTUMCYP19A1
SCHEMBL31345992 0.76 FFAR1 (0.39) FFAR1CFTRCASP3CASP7CASP8
SCHEMBL31345962 0.75 KDM1A (0.40) FFAR1CASP3CASP7CASP8TEAD1
SCHEMBL31345981 0.75 KDM1A (0.40) FFAR1CASP3CASP7CASP8TEAD1
SCHEMBL31346072 0.74 FFAR1 (0.40) FFAR1CYP19A1TEAD1
SCHEMBL31346009 0.73 FFAR1 (0.37) FFAR1NOTUMCASP3CASP7CASP8
SCHEMBL31345963 0.73 TEAD1 (0.42) FFAR1CYP19A1TEAD1
SCHEMBL31346002 0.73 TEAD1 (0.42) FFAR1CYP19A1TEAD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 EP disclosed
WO-2024239000-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST ENVEDA THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed