SCHEMBL31346002

SCHEMBL31346002

FC(F)(F)c1ccc2c(c1)C[C@@H](c1cccc(Br)c1)O2

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TEAD1 P28347 3/20 0.42
HTR1A P08908 2/20 0.41
FFAR1 O14842 6/20 0.38
CYP19A1 P11511 1/20 0.36
AR P10275 1/20 0.36
CHRM2 P08172 1/20 0.35
DRD3 P35462 1/20 0.35
HTR2B P41595 1/20 0.35
KDM1A O60341 2/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
HTR2C P28335 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31345963 1.00 TEAD1 (0.42) TEAD1HTR1AFFAR1CYP19A1AR
SCHEMBL31345984 0.88 PNMT (0.35) TEAD1HTR1AARHTR2BHTR2C
SCHEMBL31346022 0.83 FFAR1 (0.39) TEAD1FFAR1
SCHEMBL31346038 0.82 TERT (0.34) TEAD1NPC1RAB9A
SCHEMBL31346136 0.82 CYP11B1 (0.40) TEAD1
SCHEMBL31346060 0.82 TERT (0.34) TEAD1NPC1RAB9A
SCHEMBL31346117 0.81 CYP19A1 (0.45) TEAD1HTR1AFFAR1CYP19A1DRD3
SCHEMBL31345995 0.81 CYP19A1 (0.45) TEAD1HTR1AFFAR1CYP19A1DRD3
SCHEMBL31346056 0.81 TEAD1 (0.34) TEAD1
SCHEMBL31346045 0.80 TEAD1 (0.37) TEAD1HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 EP disclosed
WO-2024239000-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST ENVEDA THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed