Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.67 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.61 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3139402 | 0.90 | DRD2 (0.73) | DRD2ADRA1ADRD4DRD3MEN1 | |
| SCHEMBL3138435 | 0.86 | DRD2 (0.72) | DRD2ADRA1ADRD4DRD3MEN1 | |
| SCHEMBL3137582 | 0.84 | DRD2 (0.75) | DRD2ADRA1ADRD4DRD3MEN1 | |
| SCHEMBL9050736 | 0.82 | DRD2 (1.00) | DRD2ADRA1ADRD4DRD3MEN1 | |
| SCHEMBL8986015 | 0.82 | DRD2 (0.82) | DRD2ADRA1ADRD4DRD3MEN1 | |
| Chlorohaloperidol SCHEMBL4112719 | 0.81 | DRD2 (1.00) | DRD2ADRA1ADRD4DRD3MEN1 | |
| SCHEMBL3139717 | 0.81 | DRD2 (0.73) | DRD2ADRA1ADRD4DRD3MEN1 | |
| SCHEMBL11793314 | 0.80 | DRD2 (0.83) | DRD2ADRA1ADRD4DRD3MEN1 | |
| SCHEMBL11796046 | 0.78 | DRD2 (0.88) | DRD2ADRA1ADRD4DRD3MEN1 | |
| SCHEMBL20248950 | 0.78 | DRD2 (0.88) | DRD2ADRA1ADRD4DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004289-A1 | SUBSTITUTED BUTYROPHENONE DERIVATIVES | CLERA INC. (CA) | 2010-01-07 | — | — | US | claimed |
| EP-1874730-A4 | SUBSTITUTED BUTYROPHENONE DERIVATIVES | CLERA INC (CA) | 2009-06-10 | — | — | EP | claimed |
| EP-1874730-A1 | SUBSTITUTED BUTYROPHENONE DERIVATIVES | Clera Inc. (CA) | 2008-01-09 | — | — | EP | claimed |
| WO-2007118325-A1 | ENHANCEMENT OF MEMORY AND/OR COGNITION USING SUBSTITUTED BUTYROPHENONE COMPOUNDS | CLERA INC. (CA) | 2007-10-25 | — | — | WO | claimed |
| WO-2006116848-A1 | SUBSTITUTED BUTYROPHENONE DERIVATIVES | CLERA INC. (CA) | 2006-11-09 | — | — | WO | claimed |
| US-20100004289-A1 | SUBSTITUTED BUTYROPHENONE DERIVATIVES | CLERA INC. (CA) | 2010-01-07 | — | — | US | disclosed |
| EP-1874730-A4 | SUBSTITUTED BUTYROPHENONE DERIVATIVES | CLERA INC (CA) | 2009-06-10 | — | — | EP | disclosed |
| EP-1874730-A1 | SUBSTITUTED BUTYROPHENONE DERIVATIVES | Clera Inc. (CA) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006116848-A1 | SUBSTITUTED BUTYROPHENONE DERIVATIVES | CLERA INC. (CA) | 2006-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004289-A1 | SUBSTITUTED BUTYROPHENONE DERIVATIVES | DBH, SLC6A3, GABBR1 | DRD2 12/4885ADRA1A 513/4885DRD4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.