Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19235263 | 0.80 | HTR2A (0.51) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL19235383 | 0.77 | HTR2A (0.48) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL30721771 | 0.77 | CALCA (0.46) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL23595063 | 0.75 | OPRL1 (0.45) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL31349435 | 0.74 | MAP3K11 (0.42) | OPRM1 | |
| SCHEMBL31349620 | 0.74 | TSHR (0.46) | OPRL1OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL30340781 | 0.73 | SIGMAR1 (0.44) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL23580283 | 0.73 | SIGMAR1 (0.44) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL4952229 | 0.73 | OPRL1 (0.60) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL15650027 | 0.72 | OPRL1 (0.50) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743078-A2 | APOL1 INHIBITORS AND METHODS OF USE | Maze Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015104-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |