Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SSTR5 | P35346 | 6/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138171 | 0.92 | ALDH1A1 (0.51) | ALDH1A1ALOX15HSD17B10MAPTLMNA | |
| SCHEMBL3141833 | 0.91 | ALOX15 (0.50) | ALDH1A1ALOX15HSD17B10MAPTLMNA | |
| SCHEMBL3128237 | 0.91 | ALDH1A1 (0.49) | ALDH1A1ALOX15HSD17B10MAPTLMNA | |
| SCHEMBL3138799 | 0.89 | MAPT (0.52) | ALDH1A1ALOX15HSD17B10MAPTLMNA | |
| SCHEMBL3125839 | 0.89 | MAPK1 (0.52) | ALDH1A1ALOX15HSD17B10MAPTLMNA | |
| SCHEMBL3138758 | 0.89 | SSTR5 (0.49) | ALDH1A1ALOX15HSD17B10MAPTLMNA | |
| SCHEMBL3136065 | 0.88 | ALOX15 (0.47) | ALDH1A1ALOX15HSD17B10MAPTLMNA | |
| SCHEMBL3094039 | 0.88 | SSTR5 (0.57) | ALDH1A1ALOX15HSD17B10LMNAHTT | |
| SCHEMBL3137489 | 0.88 | ALDH1A1 (0.46) | ALDH1A1ALOX15HSD17B10MAPTLMNA | |
| SCHEMBL3137243 | 0.87 | ALOX15 (0.46) | ALDH1A1ALOX15HSD17B10MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-B1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | HOFFMANN LA ROCHE (CH) | 2010-07-07 | — | — | EP | claimed |