SCHEMBL31355774

SCHEMBL31355774

O=C1CCC(c2coc3ccc(NCc4ccc(CN5CCCCC5)c(F)c4)cc23)C(=O)N1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 8/20 0.39
▸ CRBN Q96SW2 8/20 0.39
▸ BDKRB1 P46663 7/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ CXCR3 P49682 1/20 0.34
▸ GSPT1 P15170 1/20 0.32
▸ IKZF3 Q9UKT9 1/20 0.32
▸ PREP P48147 1/20 0.32
▸ CTNNB1 P35222 1/20 0.31
▸ TCF7L2 Q9NQB0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31356209 0.92 CRBN (0.34) DDB1CRBNGSPT1IKZF3
SCHEMBL31356215 0.89 DDB1 (0.44) DDB1CRBNBDKRB1GSPT1IKZF3
SCHEMBL31356047 0.85 TRPV1 (0.43) BDKRB1
SCHEMBL31356060 0.83 CRBN (0.44) DDB1CRBNKDM4ESMN1; SMN2CXCR3
SCHEMBL31356051 0.82 CRBN (0.41) DDB1CRBNGSPT1IKZF3
SCHEMBL31355867 0.82 DDB1 (0.49) DDB1CRBNBDKRB1KDM4ESMN1; SMN2
SCHEMBL31355861 0.80 SIGMAR1 (0.39) DDB1CRBN
SCHEMBL31356009 0.80 SIGMAR1 (0.39) DDB1CRBN
SCHEMBL31355996 0.80 SIGMAR1 (0.39) DDB1CRBN
SCHEMBL31355906 0.78 DDB1 (0.58) DDB1CRBNKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119768392-A Aryl or heteroaryl substituted glutarimide derivatives and uses thereof 标新生物医药科技(上海)有限公司 2025-04-04 — — CN claimed
WO-2025026422-A1 ARYL OR HETEROARYL SUBSTITUTED GLUTARIMIDE DERIVATIVE AND USE THEREOF 标新生物医药科技(上海)有限公司 2025-02-06 — — WO claimed
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