Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.67 |
| ▸ | CCR1 | P32246 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 5/20 | 0.45 |
| ▸ | ACHE | P22303 | 5/20 | 0.45 |
| ▸ | BACE1 | P56817 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3144419 | 0.90 | ABCB11 (0.59) | ABCB11CCR1BCHEACHEBACE1 | |
| SCHEMBL30172191 | 0.87 | ABCB11 (0.69) | ABCB11CCR1BCHEACHEBACE1 | |
| SCHEMBL1682973 | 0.87 | ABCB11 (0.69) | ABCB11CCR1BCHEACHEBACE1 | |
| SCHEMBL3150386 | 0.87 | ABCB11 (0.69) | ABCB11CCR1BCHEACHEBACE1 | |
| SCHEMBL3135724 | 0.86 | ABCB11 (0.72) | ABCB11CCR1BCHEACHEBACE1 | |
| SCHEMBL3145745 | 0.84 | ABCB11 (0.70) | ABCB11CCR1BCHEACHEBACE1 | |
| SCHEMBL3144689 | 0.83 | ABCB11 (0.69) | ABCB11CCR1BCHEACHEBACE1 | |
| SCHEMBL4712843 | 0.83 | ABCB11 (0.69) | ABCB11CCR1BCHEACHEBACE1 | |
| Trifluoroacetic Acid SCHEMBL3149755 | 0.82 | ABCB11 (0.67) | ABCB11CCR1BCHEACHEBACE1 | |
| SCHEMBL3053294 | 0.82 | ABCB11 (0.69) | ABCB11CCR1BCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100081692-A1 | Novel 1-Benzyl-4-Piperidinamines that are Useful in the Treatment of COPD and Asthma | ASTRAZENECA AB (SE) | 2010-04-01 | — | — | US | disclosed |
| EP-1945613-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007053082-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081692-A1 | Novel 1-Benzyl-4-Piperidinamines that are Useful in the Treatment of COPD and Asthma | CCR1, CCR4, CCR10 | ABCB11 477/4885CCR1 1/4885BCHE 959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.