SCHEMBL31355860

SCHEMBL31355860

O=C1CCC(N2C(=O)c3cccc4c(NC(=O)CCCCCCCN5CCC(F)(F)CC5)ccc2c34)C(=O)N1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 1/20 0.48
HDAC3 O15379 5/20 0.43
HDAC1 Q13547 5/20 0.43
HDAC2 Q92769 5/20 0.43
NCOR2 Q9Y618 5/20 0.43
PTK2 Q05397 6/20 0.43
BCL2 P10415 5/20 0.42
MCL1 Q07820 5/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 1/20 0.42
CRBN Q96SW2 2/20 0.42
DDB1 Q16531 1/20 0.42
ABL1 P00519 1/20 0.42
BCR P11274 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31485123 1.00 PIK3CA (0.48) PIK3CAHDAC3HDAC1HDAC2NCOR2
SCHEMBL31355952 0.92 PIK3CA (0.48) PIK3CAHDAC3HDAC1HDAC2NCOR2
SCHEMBL31485112 0.91 PARP1 (0.46) PIK3CAHDAC3HDAC1HDAC2NCOR2
SCHEMBL31485142 0.90 PIK3CA (0.55) PIK3CAHDAC3HDAC1HDAC2NCOR2
SCHEMBL31356115 0.88 CRBN (0.44) PIK3CAHDAC3HDAC1HDAC2NCOR2
SCHEMBL31485116 0.88 CRBN (0.44) PIK3CAHDAC3HDAC1HDAC2NCOR2
SCHEMBL31356102 0.88 BCL2 (0.43) HDAC3HDAC1HDAC2NCOR2BCL2
SCHEMBL31355761 0.88 BCL2 (0.43) HDAC3HDAC1HDAC2NCOR2BCL2
SCHEMBL31484986 0.84 PARP1 (0.46) PIK3CAHDAC3HDAC1HDAC2NCOR2
SCHEMBL31355994 0.84 ALDH1A1 (0.48) HDAC3HDAC1HDAC2NCOR2BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119768392-A Aryl or heteroaryl substituted glutarimide derivatives and uses thereof 标新生物医药科技(上海)有限公司 2025-04-04 CN claimed
WO-2025026422-A1 ARYL OR HETEROARYL SUBSTITUTED GLUTARIMIDE DERIVATIVE AND USE THEREOF 标新生物医药科技(上海)有限公司 2025-02-06 WO claimed