Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.45 |
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31357860 | 0.90 | ESR2 (0.51) | ESR2MAPK1NR1H2UCHL1SCN9A | |
| SCHEMBL29554774 | 0.89 | ESR2 (0.52) | ESR2MAPK1NR1H2UCHL1SCN9A | |
| SCHEMBL5880442 | 0.89 | ESR2 (0.52) | ESR2MAPK1NR1H2UCHL1SCN9A | |
| SCHEMBL21807447 | 0.89 | DDB1 (0.51) | ESR2MAPK1NR1H2UCHL1SCN9A | |
| SCHEMBL17686937 | 0.85 | UCHL1 (0.49) | ESR2MAPK1NR1H2UCHL1SCN9A | |
| SCHEMBL16269155 | 0.85 | UCHL1 (0.49) | ESR2MAPK1NR1H2UCHL1SCN9A | |
| SCHEMBL25381833 | 0.84 | UCHL1 (0.48) | ESR2MAPK1NR1H2UCHL1SCN9A | |
| SCHEMBL17687240 | 0.84 | UCHL1 (0.51) | ESR2MAPK1NR1H2UCHL1SCN9A | |
| SCHEMBL30678892 | 0.84 | UCHL1 (0.48) | ESR2MAPK1NR1H2UCHL1SCN9A | |
| SCHEMBL16269668 | 0.84 | UCHL1 (0.51) | ESR2MAPK1NR1H2UCHL1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119241559-A | Quinazoline macrocyclic compound serving as HPK1 kinase inhibitor and preparation method and application thereof | 深圳市新樾生物科技有限公司 | 2025-01-03 | — | — | CN | disclosed |