Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19648359 | 0.84 | PIK3CB (0.46) | PIK3CBCDC7PDPK1NOS3NOS1 | |
| SCHEMBL21958683 | 0.78 | MAPK1 (0.43) | CDC7MAPK1TRPM5USP7CYP11B2 | |
| SCHEMBL7920620 | 0.78 | CYP1A2 (0.42) | CDC7MAPK1TRPM5CYP11B2TRPA1 | |
| SCHEMBL12535873 | 0.76 | TRPM5 (0.43) | CDC7MAPK1TRPM5SRCCYP11B2 | |
| SCHEMBL12384973 | 0.76 | MAPK1 (0.39) | CDC7MAPK1TRPM5CYP11B2TRPA1 | |
| SCHEMBL30754802 | 0.76 | MAPK1 (0.39) | CDC7MAPK1TRPM5CYP11B2TRPA1 | |
| SCHEMBL27274089 | 0.74 | AR (0.44) | CDC7MAPK1CHEK1AURKADAPK3 | |
| SCHEMBL10183335 | 0.73 | MAPK1 (0.39) | CDC7MAPK1TRPM5SRCCYP11B2 | |
| SCHEMBL10233457 | 0.73 | TRPM5 (0.38) | CDC7MAPK1TRPM5USP7CYP11B2 | |
| SCHEMBL15341870 | 0.73 | MAPK1 (0.43) | PIK3CBCDC7MAPK1TRPM5CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4727647-A1 | GLYCOGEN SYNTHASE KINASE 3 INHIBITORS AND USES THEREOF | The Broad Institute Inc. (US) | 2026-04-22 | — | — | EP | disclosed |
| US-20260103465-A1 | GLYCOGEN SYNTHASE KINASE 3 INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2026-04-16 | — | — | US | disclosed |
| WO-2024259178-A1 | GLYCOGEN SYNTHASE KINASE 3 INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2024-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260103465-A1 | GLYCOGEN SYNTHASE KINASE 3 INHIBITORS AND USES THEREOF | GSK3A, GSK3B, GYS2 | PIK3CB 1210/4885CDC7 1061/4885PDPK1 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.