Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | PPM1G | O15355 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.59 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.59 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.59 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | POLB | P06746 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.56 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5993464 | 0.81 | GSK3A (0.67) | GSK3AGSK3BIGF1RMAPTPOLB | |
| SCHEMBL31358762 | 0.81 | PIK3CG (0.60) | PPM1GPTPN1PTPN7PTPN5PTPRO | |
| SCHEMBL3771633 | 0.80 | GSK3A (0.80) | GSK3AGSK3BIGF1RPOLBMEN1 | |
| SCHEMBL31358773 | 0.80 | MEN1 (0.69) | PPM1GPTPN1PTPN7PTPN5PTPRO | |
| SCHEMBL31358844 | 0.79 | MEN1 (0.60) | GSK3AGSK3BPPM1GPTPN1PTPN7 | |
| SCHEMBL31358729 | 0.74 | MAPT (0.69) | PPM1GPTPN1PTPN7PTPN5PTPRO | |
| SCHEMBL13479578 | 0.74 | MEN1 (0.69) | PPM1GPTPN1PTPN7PTPN5PTPRO | |
| SCHEMBL31358681 | 0.74 | MEN1 (0.69) | PPM1GPTPN1PTPN7PTPN5PTPRO | |
| SCHEMBL31358767 | 0.74 | MAPT (0.58) | GSK3AGSK3BPPM1GPTPN1PTPN7 | |
| SCHEMBL31358707 | 0.74 | MAPT (0.65) | GSK3AGSK3BPPM1GPTPN1PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | GSK3A 843/4885GSK3B 787/4885PPM1G 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.