Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.80 |
| ▸ | GSK3B | P49841 | 1/20 | 0.80 |
| ▸ | IGF1R | P08069 | 1/20 | 0.65 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.63 |
| ▸ | BRAF | P15056 | 6/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5463774 | 0.92 | GSK3A (0.68) | GSK3AGSK3BIGF1RDUSP3BRAF | |
| SCHEMBL5993464 | 0.91 | GSK3A (0.67) | GSK3AGSK3BIGF1RDUSP3BRAF | |
| SCHEMBL12632706 | 0.86 | GSK3A (0.61) | GSK3AGSK3BIGF1RDUSP3BRAF | |
| SCHEMBL5147292 | 0.83 | PIK3CG (0.71) | GSK3AGSK3BDUSP3BRAFSIRT2 | |
| SCHEMBL3907984 | 0.82 | IGF1R (0.81) | GSK3AGSK3BIGF1RDUSP3PIK3CG | |
| SCHEMBL3907981 | 0.82 | IGF1R (0.81) | GSK3AGSK3BIGF1RDUSP3PIK3CG | |
| SCHEMBL31358728 | 0.80 | GSK3A (0.59) | GSK3AGSK3BIGF1RDUSP3MEN1 | |
| SCHEMBL5997094 | 0.76 | BRAF (1.00) | GSK3AGSK3BIGF1RBRAFSIRT2 | |
| SCHEMBL6397299 | 0.75 | BRAF (0.68) | GSK3AGSK3BBRAFSIRT2SIRT1 | |
| SCHEMBL13587001 | 0.75 | SIRT2 (0.80) | GSK3AGSK3BIGF1RBRAFSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065139-A2 | ENTPD5 INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-05-18 | — | — | WO | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | GSK3A 3338/4885GSK3B 3324/4885IGF1R 610/4885 |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | GSK3A 3338/4885GSK3B 3324/4885IGF1R 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.