Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.73 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.65 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | POLB | P06746 | 7/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.58 |
| ▸ | APEX1 | P27695 | 4/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31358731 | 0.91 | AKT1 (0.77) | AKT1PTPN5KMT2AKDM4EPOLB | |
| SCHEMBL31358776 | 0.85 | SIRT2 (0.62) | AKT1KEAP1NFE2L2PTPN5KMT2A | |
| SCHEMBL6720217 | 0.85 | AKT1 (1.00) | AKT1PTPN5KMT2AKDM4EPOLB | |
| SCHEMBL31358662 | 0.85 | AKT1 (1.00) | AKT1PTPN5KMT2AKDM4EPOLB | |
| SCHEMBL31358895 | 0.84 | AKT1 (0.77) | AKT1KEAP1NFE2L2PTPN5KMT2A | |
| SCHEMBL31358872 | 0.82 | KMT2A (0.60) | AKT1KEAP1NFE2L2PTPN5KMT2A | |
| SCHEMBL31358710 | 0.80 | MEN1 (0.68) | AKT1KEAP1NFE2L2PTPN5KMT2A | |
| SCHEMBL31358829 | 0.80 | AKT1 (0.67) | AKT1PTPN5KMT2AKDM4EPOLB | |
| SCHEMBL31358693 | 0.80 | AKT1 (0.58) | AKT1PTPN5KMT2AKDM4EPOLB | |
| SCHEMBL5145235 | 0.80 | AURKA (0.78) | KEAP1NFE2L2KMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | AKT1 194/4885KEAP1 1197/4885NFE2L2 4028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.