Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.78 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.78 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.75 |
| ▸ | BRAF | P15056 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.63 |
| ▸ | GSK3A | P49840 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 3/20 | 0.60 |
| ▸ | APEX1 | P27695 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147286 | 0.90 | GSK3A (0.76) | AURKAAURKBSIRT2BRAFKDM4E | |
| SCHEMBL5147289 | 0.90 | GSK3A (0.76) | AURKAAURKBSIRT2BRAFKDM4E | |
| SCHEMBL1435462 | 0.88 | AURKA (1.00) | AURKAAURKBSIRT2BRAFKDM4E | |
| SCHEMBL5994115 | 0.86 | SIRT2 (1.00) | AURKAAURKBSIRT2BRAFKMT2A | |
| SCHEMBL13587001 | 0.83 | SIRT2 (0.80) | AURKAAURKBSIRT2BRAFKDM4E | |
| SCHEMBL1064843 | 0.83 | GSK3A (0.81) | AURKAAURKBSIRT2BRAFKMT2A | |
| SCHEMBL1067629 | 0.82 | BRAF (0.85) | AURKAAURKBBRAFKDM4EKMT2A | |
| SCHEMBL1067626 | 0.82 | BRAF (0.85) | AURKAAURKBBRAFKDM4EKMT2A | |
| SCHEMBL5164488 | 0.82 | KMT2A (0.71) | AURKAAURKBSIRT2KDM4EKMT2A | |
| SCHEMBL5145124 | 0.81 | GSK3A (0.76) | AURKAAURKBSIRT2KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718308-A4 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORP (CA) | 2007-07-18 | — | — | EP | disclosed |
| EP-1718308-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PainCeptor Pharma Corp. (CA) | 2006-11-08 | — | — | EP | disclosed |
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-12-22 | — | — | US | disclosed |
| WO-2005076695-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | NGF, BDNF, NTRK2 | AURKA 4704/4885AURKB 3812/4885SIRT2 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.