Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.37 |
| ▸ | CDK2 | P24941 | 7/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136001 | 1.00 | MAPK1 (0.40) | MAPK1LMNATHRBCCNE1CDK2 | |
| SCHEMBL3559144 | 0.89 | CCNE1 (0.36) | MAPK1CCNE1CDK2ROCK2GSK3B | |
| SCHEMBL3559145 | 0.89 | CCNE1 (0.36) | MAPK1CCNE1CDK2ROCK2GSK3B | |
| SCHEMBL3565829 | 0.78 | CCR2 (0.34) | CCNE1CDK2GSK3BCETP | |
| SCHEMBL3557896 | 0.74 | ALDH1A1 (0.44) | CDK2 | |
| SCHEMBL3557894 | 0.74 | ALDH1A1 (0.44) | CDK2 | |
| SCHEMBL3559398 | 0.74 | CDK2 (0.43) | CCNE1CDK2GSK3B | |
| SCHEMBL3559395 | 0.74 | CDK2 (0.43) | CCNE1CDK2GSK3B | |
| SCHEMBL5597648 | 0.74 | MAPK1 (0.51) | MAPK1LMNAROCK2ANPEPEPHX2 | |
| SCHEMBL3561897 | 0.71 | CCR2 (0.40) | CDK2CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689721-B1 | AMINOPYRAZOLE DERIVATIVES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2010-07-14 | — | — | EP | claimed |
| US-7671072-B2 | Aminopyrazole derivatives as GSK-3 inhibitors | PFIZER INC. (US) | 2010-03-02 | — | — | US | claimed |
| EP-1689721-B1 | AMINOPYRAZOLE DERIVATIVES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2010-07-14 | — | — | EP | disclosed |