Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.56 |
| ▸ | HTR2C | P28335 | 8/20 | 0.56 |
| ▸ | HTR2B | P41595 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 4/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4845606 | 0.90 | HTR2A (0.47) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| Fumaric Acid SCHEMBL4845619 | 0.90 | HTR2A (0.47) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL6360534 | 0.84 | HTR2A (0.55) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL905840 | 0.80 | HTR2C (0.58) | HTR2AHTR2CHTR2BSLC22A12 | |
| SCHEMBL18853871 | 0.80 | ESR1 (0.63) | ESR1KMOADORA2AADORA2BSLC22A12 | |
| SCHEMBL6364909 | 0.78 | GLS (0.57) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| Fumaric Acid SCHEMBL7098345 | 0.78 | HTR2C (0.40) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| Fumaric Acid SCHEMBL7098346 | 0.78 | HTR2C (0.40) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL4845615 | 0.77 | SLC22A12 (0.42) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| Fumaric Acid SCHEMBL6361127 | 0.76 | HTR2A (0.46) | HTR2AHTR2CHTR2BHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513589-B1 | 1,5-DISUBSTITUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA | MERCK FROSST CANADA LTD (CA) | 2010-11-10 | — | — | EP | claimed |
| EP-1613621-B1 | PROSTAGLANDIN ANALOGS AS EP4 RECEPTOR AGONISTS | MERCK FROSST CANADA LTD (CA) | 2010-07-21 | — | — | EP | claimed |
| EP-1663987-B1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-03-18 | — | — | EP | claimed |
| US-6956036-B1 | 6-hydroxy-indazole derivatives for treating glaucoma | ALCON, INC. (CH) | 2005-10-18 | — | — | US | disclosed |