Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 10/20 | 0.49 |
| ▸ | HTR2A | P28223 | 9/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5678010 | 0.88 | GLS (0.46) | GLSHTR2CHTR2ACHRM2CHRM1 | |
| Fumaric Acid SCHEMBL5678017 | 0.88 | GLS (0.46) | GLSHTR2CHTR2ACHRM2CHRM1 | |
| SCHEMBL19675194 | 0.86 | GLS (0.60) | GLSCHRM2CHRM1LMNASMN1; SMN2 | |
| SCHEMBL3136016 | 0.78 | HTR2A (0.56) | HTR2CHTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL6090368 | 0.77 | GLS (0.66) | GLSLMNASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL905840 | 0.76 | HTR2C (0.58) | HTR2CHTR2AHTR2B | |
| SCHEMBL15241840 | 0.75 | GLS (0.64) | GLSCHRM2CHRM1LMNASMN1; SMN2 | |
| SCHEMBL905693 | 0.74 | ADORA2A (0.45) | HTR2CHTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL19596918 | 0.74 | GLS (0.72) | GLSLMNAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL13777341 | 0.72 | L3MBTL1 (0.62) | GLSCHRM2CHRM1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956036-B1 | 6-hydroxy-indazole derivatives for treating glaucoma | ALCON, INC. (CH) | 2005-10-18 | — | — | US | disclosed |