Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 10/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31361199 | 0.81 | CD274 (0.44) | LTA4HCD274PDCD1PDCD1LG2BRD4 | |
| SCHEMBL31416747 | 0.79 | RPS6KB1 (0.34) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL17403601 | 0.77 | CD274 (0.41) | LTA4HCD274PDCD1PDCD1LG2EGLN2 | |
| SCHEMBL25747431 | 0.75 | CD274 (0.37) | CD274PDCD1PDCD1LG2EGLN2KCNH2 | |
| SCHEMBL24046980 | 0.75 | CD274 (0.37) | CD274PDCD1PDCD1LG2EGLN2KCNH2 | |
| SCHEMBL610614 | 0.74 | LTA4H (0.43) | LTA4HCD274PDCD1BRD4EGLN2 | |
| SCHEMBL16132160 | 0.72 | CD274 (0.43) | LTA4HCD274PDCD1PDCD1LG2BRD4 | |
| SCHEMBL25747414 | 0.71 | SLC16A3 (0.44) | CD274PDCD1LG2KCNH2MCHR1 | |
| SCHEMBL20332369 | 0.70 | MAP4K4 (0.38) | LTA4HKCNH2 | |
| SCHEMBL18291540 | 0.69 | CXCR4 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746965-A1 | BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| EP-4746964-A1 | NEW PYRAZOLOPYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2026046976-A1 | PYRAZOLOPYRIDINE PHOSPHATE ESTERS FOR MODULATING SALT-INDUCIBLE KINASE (SIK) | F. HOFFMANN-LA ROCHE AG (CH) | 2026-03-05 | — | — | WO | disclosed |
| WO-2025017041-A1 | BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-23 | — | — | WO | disclosed |
| WO-2025017078-A1 | NEW PYRAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-23 | — | — | WO | disclosed |