Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905910 | 0.73 | — | — | |
| SCHEMBL201126 | 0.73 | — | — | |
| SCHEMBL7078914 | 0.71 | MAOA (0.31) | ALDH1A1MAPTMEN1LMNAPOLB | |
| SCHEMBL29161382 | 0.63 | MAPT (0.54) | ALDH1A1MAPTMEN1LMNAPOLB | |
| SCHEMBL31231126 | 0.62 | — | — | |
| SCHEMBL28728640 | 0.61 | MAPT (0.41) | ALDH1A1MAPTMEN1LMNAPOLB | |
| SCHEMBL1924981 | 0.60 | MAPT (0.38) | ALDH1A1MAPTMEN1LMNAPOLB | |
| SCHEMBL730638 | 0.60 | MAPT (0.35) | ALDH1A1MAPTMEN1LMNAPOLB | |
| SCHEMBL4515373 | 0.60 | ALDH1A1 (0.32) | ALDH1A1MAPTMEN1LMNAPOLB | |
| SCHEMBL8102526 | 0.60 | MAP2K7 (0.42) | ALDH1A1MAPTMEN1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |